1. an act causing pain or damage

2. the act of imposing something (as a tax or an embargo)

Synonym: imposition

3. something or someone that causes trouble
a source of unhappiness

e.g. washing dishes was a nuisance before we got a dish washer
a bit of a bother
he's not a friend, he's an infliction

Synonym: annoyancebotherbotherationpainpain in the neckpain in the ass